The actress has played Susan Mayer in all seven series of the drama since it hit screens in 2004.
But Hatcher has reportedly told executives at America's ABC network the next season will be her last, so she can work on a new show.
A source said, "Teri has given in her notice and is making active preparations to move on."
"She has another production deal in the pipeline and she is in the early stages of developing a sitcom that she wants to start work on immediately after she finishes Desperate Housewives - she wants a new show in time for the mid-January pilot season."
The report also suggests Hatcher's co-star Felicity Huffman is planning to leave her role as Lynette Scavo after season eight.
It continues, "ABC hasn't announced its schedule yet because the future of the series is up in the air. Some of the crew are disappointed in Teri, they feel like she is abandoning the show that revived her career.
"Desperate Housewives can't really continue without Teri or Felicity because they need the original stars to pull in the ratings. She (Hatcher) says she had an amazing run on the show but feels it is time to move on to a project that she has more control over."
A spokesperson for ABC says, "We are working on the next season at the moment and we haven't got anything to say about the one after."